Hướng nghiên cứu cảm biến quang học trong kỹ thuật y sinh

Hướng nghiên cứu:
1. Thiết kế cảm biến sợi quang học trong kỹ thuật y sinh ứng dụng trong chẩn đoán: (chẩn đoán bệnh như bệnh tim, ung thư dạ dày…)
2. Cảm biến y-sinh học cộng hưởng plasmon bề mặt định xứ (LSPR) có độ nhạy cao nhờ vào tán xạ Raman tăng cường bề mặt (SERS)
3. Xây dựng, thiết kế và chế tạo các cảm biến cộng hưởng plasmon bề mặt tăng cường tín hiệu huỳnh quang ứng dụng để phát hiện, chẩn đoán mức độ phân tử

Liên hệ: TS. Trần Thị Như Hoa, Email: ttnhoa@hcmus.edu.vn

Các công trình Công bố khoa học trên các tạp chí Quốc tế:

1. Dung, Cao Thi My; Thi, Nhu Hoa Tran; Ta, Kieu Hanh Thi; Tran, Vinh Cao; Nguyen, Bao Thu Le; Le, Van Hieu; Do, Phuong Anh; Dang, Anh Tuan; Ju, Heongkyu; Phan, Bach Thang. Relaxor Behaviors in XBaTiO₃–(1-X)CoFe₂O₄. Journal of Magnetics 2005, 20, 353–359. Doi: 10.4283/JMAG.2015.20.4.353. (Co-first author)
2. Tran, N. H. T.; Phan, B. T.; Yoon, W. J.; Khym, S.; Ju, H. Dielectric Metal-Based Multilayers for Surface Plasmon Resonance with Enhanced Quality Factor of the Plasmonic Waves. J. Electron. Mater. 2017, 46, 3654–3659. Doi:10.1007/s11664-017-5375-2.
3. Ta, T. K. H.; Tran, T. N. H.; Tran, Q. M. N.; Pham, D. P.; Pham, K. N.; Cao, T. T.; Kim, Y. S.; Tran, D. L.; Ju, H.; Phan, B. T. Surface Functionalization of WO₃ Thin Films with (3-Aminopropyl)triethoxysilane and Succinic Anhydride. J. Electron. Mater. 2017, 46, 3345–3352. Doi:10.1007/s11664-017-5408-x.
4. Tran, N. H. T.; Kim, J.; Phan, T. B.; Khym, S.; Ju, H. Label-Free Optical Biochemical Sensors via Liquid-Cladding-Induced Modulation of Waveguide Modes. ACS Appl. Mater. Interfaces 2017, 9, 31478-31487. Doi:10.1021/acsami.7b09252.
5. Vu Nu, T. T.; Tran, N. H. T.; Nam, E.; Nguyen, T. T.; Yoon, W. J.; Cho, S.; Kim, J.; Chang, K. A.; Ju, H. Blood-Based Immunoassay of Tau Proteins for Early Diagnosis of Alzheimer’s Disease using Surface Plasmon Resonance Fiber Sensors. RSC Adv. 2018, 8, 7855–7862. Doi:10.1039/c7ra11637c. (Co-first author)
6. Tran, N. H. T.; Trinh, K. T. L.; Lee, J.-H.; Yoon, W. J.; Ju, H. Reproducible Enhancement of Fluorescence by Bimetal Mediated Surface Plasmon Coupled Emission for Highly Sensitive Quantitative Diagnosis of Double-Stranded DNA. Small 2018, 4, 1801385. Doi:10.1002/smll.201801385.
7. Tran, N. H. T.; Trinh, K. T. L.; Lee, J.-H.; Yoon, W. J.; Ju, H. Fluorescence Enhancement Using Bimetal Surface Plasmon-Coupled Emission from 5-Carboxyfluorescein (FAM). Micromachines 2018, 9, 460. Doi: 10.3390/mi9090460.
8. Tran, V. T.; Tran, N. H. T.; Nguyen, T. T.; Yoon, W. J.; Ju, H. Liquid Cladding Mediated Optical Fiber Sensors for Copper Ion Detection. Micromachines 2018, 9, 471. Doi: 10.3390/mi9090471.
9. Anh, Do Phuong; Hoa, Tran Thi Nhu; Van Thinh, Nguyen; Tung, Vo Thanh; Van Chuong, Truong. The Crystalline Microstructure, Surface Morphology and Ferroelectric Properties of β -Phase in the Poly(Vinylidene Fluoride)/Carbon Nanotubes (PVDF/CNTs) Composite Thin Film Using the Electrospinning Approach. Materials Focus 2018, 7, 873-878. Doi: 10.1166/mat.2018.1601.
10. Phuong Que Tran Do, Vu Thi Huong, Nguyen Tran Truc Phuong, Thi-Hiep Nguyen, Hanh Kieu Thi Ta, Heongkyu Ju, Thang Bach Phan, Viet-Duc Phung, Kieu The Loan Trinh, Nhu Hoa Thi Tran. The highly sensitive determination of serotonin by using gold nanoparticles (Au NPs) with a localized surface plasmon resonance (LSPR) absorption wavelength in the visible region. RSC Adv., 2020,10, 30858-30869. Doi: 10.1039/D0RA05271J.
11. Vu Thi Huong, Vinh Van Tran, Nae Yoon Lee, Dung Van Hoang, Kieu The Loan Trinh, Thang Bach Phan, Nhu Hoa Thi Tran. Bimetallic thin-film combination of surface plasmon resonance-based optical fiber cladding with the polarizing homodyne balanced detection method and biomedical assay application. Langmuir 2020, 36, 9967–9976. Doi: 10.1021/acs.langmuir.0c01793.
12. Anh Tuan Thanh Pham, Phuong Thanh Ngoc Vo, Hanh Kieu Thi Ta, Ngoc Kim Pham, Hoa Thi Lai, Hoa Nhu Thi Tran, Vinh Cao Tran, Tan Le Hoang Doan, Sungkyun Park, Thang Bach Phan. Dopants and induced residual stress-controlled thermoelectric properties of ZnO thin films. Materials Science and Engineering B 2020, 261, 114712. Doi: 10.1016/j.mseb.2020.114712
13. Nhu Hoa Thi Tran, Than Thi Nguyen, Thang Bach Phan, Heongkyu Ju. Coupling of Silver Nanoparticle-conjugated Fluorescent Dyes into Optical Fiber Modes for Enhanced Signal-to-noise Ratio. Biosensors and Bioelectronics 176, 2021, 112900. Doi: 10.1016/j.bios.2020.112900.
14. Vinh Van Tran, Nhu Hoa Thi Tran*, Hye Suk Hwang, Mincheol Chang, Development strategies of conducting polymer-based electrochemical biosensors for virus biomarkers: Potential for rapid COVID-19 detection, Biosensors and Bioelectronics, 182, 2021, 113192 (*co-first). Doi: 10.1016/j.bios.2021.113192.
15. Vu Thi Huong, Nguyen Tran Truc Phuong, Nguyen Tien Tai, Nguyen Thuy An, Vu Dinh Lam, Do Hung Manh, Tran Thi Kim Chi, Ngoc Xuan Dat Mai, Viet-Duc Phung and Nhu Hoa Thi Tran, Gold Nanoparticles Modified a Multimode Clad-Free Fiber for Ultrasensitive Detection of Bovine Serum Albumin, Journal of Nanomaterials, 2021, 5530709. Doi: 10.1155/2021/5530709.
16. Nguyen Thanh Thao,   Thi Xoan Hoang,   Thang Bach Phan,   Jae Young Kim,   Hanh Kieu Thi Ta,   Kieu The Loan Trinh  and  Nhu Hoa Thi Tran. A metal-enhanced sensing platform for highly sensitive detection of C-Reactive Protein antibody and Rhodamine B, applications for cardiovascular disease and food safety. Dalton Trans., 2021, 50, 6962 - 6974. Doi: 10.1039/D0DT04353B.
17. Phuong Que Do Tran, Tran Duc Trung, Bach Thang Phan, Hanh Kieu Thi Ta, Ngoc Xuan Dat Mai, Lai Thi Hoa, Thanh Van Thi Tran, Dung Van Hoang, Nhu Hoa Thi Tran. Gold nanoparticles enhanced fluorescence for highly sensitive biosensors based on localized surface plasmon resonance (LSPR) applied in determination C-reactive protein (CRP), Science and Technology Development Journal 24 (1), 2021, 867-874.
18. Vu Thi Huong, Hanh Kieu Thi Ta, Ngoc Xuan Dat Mai, Thi Thanh Van Tran, Bui Xuan Khuyen, Kieu The Loan Trinh, Nae Yoon Lee, Bach Thang Phan, and Nhu Hoa Thi Tran, Development of a highly sensitive sensor chip using optical diagnostic based on functionalized plasmonically active AuNPs. Nanotechnology,  2021, 32, 335505. Doi: 10.1088/1361-6528/ac0080.
19. Book chapter: Use of herbal extract for body care formulation in Nanotechnology for the Preparation of Cosmetics using Plant-based Extracts, Nhu Hoa Thi Tran, Van Vinh Tran, Thi Vu Nu Truong, Khac Hoang Vu Bui. Editor: Mohammad Jawaid, Siti Hamidah Mohd Setapar, Akil AhmadPublisher, 2022, Elsevier Science Publishing Co Inc, ISBN: 9780128229675.
20. Nhu Hoa Thi Tran, Viet-Duc Phung, Hanh Kieu Thi Ta, Vu Dinh Lam, Do Hung Manh, Ngoc Kim Pham, Jae Young Kim, Nae Yoon Lee, Bach Thang Phan, Ultrasensitive biosensors based on waveguide-coupled long-range surface plasmon resonance (WC-LRSPR) for enhanced fluorescence spectroscopy. RSC Adv., 2021, 11, 22450 - 22460. Doi: 10.1039/D1RA02130C.
21. N.T.T. Phuong, T.X. Hoang, N.L.N. Tran, L.G. Phuc, V.D. Phung, H.K.T Ta, T.N. Bach, N.H.T Tran, K.T.L Trinh, Rapid and sensitive detection of Rhodamine B in food using the plasmonic silver nanocube-based sensor as SERS active substrate. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 263 120179.
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